Virology Services

The WNPRC Virology Services Unit provides expert support to investigators performing virological research in nonhuman primates. Our services include highly sensitive molecular diagnostics, production and titration of virus stocks suitable for in-vitro and/or in-vivo studies, generation of custom virus mutants by reverse genetics, virus isolation and more. Our clients include investigators studying the nonhuman primate AIDS viruses simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV), influenza, Zika virus and dengue, among other viruses.



  • Detection of viral RNA by ultrasensitive quantitative RT-PCR (QRT-PCR). Viral targets include
    • SIV/SHIV
    • Simultaneous quantification of wild-type SIV and nef deletion mutants
    • Cytomegalovirus (from rhesus and cynomolgus macaques)
    • Influenza viruses
    • Zika virus
    • Dengue virus
    • Yellow fever virus 17D
    • Simian arteriviruses
  • Production of characterized virus stocks:
  • Production of custom SIV mutants
  • Isolation of nonhuman primate viruses in tissue culture
  • Assays to measure the latent reservoir of SIV:
    • Quantitative viral outgrowth assay (download our QVOA white paper.pdf)
    • Quantification of cell-associated SIV DNA by QPCR

For more information, please contact Virology Services Unit Head Thomas Friedrich, Ph.D. or

To request service, please complete the Virology Services Service Request Form.


Virology Services pricing as of 5/1/24


Colorful illustrations by artist David S Goodsell of SARS-CoV2 virus and Zika virus.
Left: SCV2 Life Cycle Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-023 Integrative illustration for coronavirus outreach (2020) PLoS Biol 18: e3000815 doi: 10.1371/journal.pbio.3000815. Right: Zika Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-015