A dopamineric neuron grown from an induced pluripotent stem cell for Parkinson's disease research by Su-Chun Zhang and Marina Emborg ((S-C Zhang lab photo).

Dopaminergic neuron grown from stem cells by the Emborg and Zhang groups

WNPRC scientific journal articles

Wisconsin National Primate Research Center references are listed courtesy of WNPRC staff and PubMed, National Library of Medicine. If you do not see your publication on this list and it involved the use of center resources or staff in part or in full, please contact us. Please acknowledge the Wisconsin National Primate Research Center and grant number P51 OD011106 in your manuscripts.

To access preprints, please search medrxiv and biorxiv and enter Wisconsin National Primate Research Center and other terms (e.g., “Wisconsin National Primate Research Center SARS CoV-2”). PLoS Negl Trop Dis. 2022 Aug 4;16(8)

DECEMBER 2022

Schmidt JK, Kim YH, Strelchenko N, Gierczic SR, Pavelec D, Golos TG, Slukvin II. Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits. Front Genome Ed. 2023 Jan 12;4:1031275.

Zhang J, Webster S, Duffin B, Bernstein MN, Steill J, Swanson S, Forsberg MH, Bolin J, Brown ME, Majumder A, Capitini CM, Stewart R, Thomson JA, Slukvin II. Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies. Stem Cell Reports. 2022 Dec 28:S2213-6711(22)00604-X.

Saalmann YB, Mofakham S, Mikell CB, Djuric PM. Microscale multicircuit brain stimulation: Achieving real-time brain state control for novel applications. Curr Res Neurobiol. 2022 Dec 29;4:100071.

Ziegler TE, Tardif SD, Ross CN, Snowdon CT, Kapoor A, Rutherford JN. Timing of the luteal-placental shift is delayed with additional fetuses in litter-bearing callitrichid monkeys, Saguinus oedipus and Callithrix jacchus. Gen Comp Endocrinol. 2022 Dec 20;333:114195.

Davey BC, Pampusch MS, Cartwright EK, Abdelaal HM, Rakasz EG, Rendahl A, Berger EA, Skinner PJ. Development of an anti-CAR antibody response in SIV-infected rhesus macaques treated with CD4-MBL CAR/CXCR5 T cells. Front Immunol. 2022 Dec 13;13:1032537.

Metzger JM, Wang Y, Neuman SS, Snow KJ, Murray SA, Lutz CM, Bondarenko V, Felton J, Gimse K, Xie R, Li D, Zhao Y, Flowers MT, Simmons HA, Roy S, Saha K, Levine JE, Emborg ME, Gong S. Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins. Biomaterials. 2022 Dec 13;293:121959. 

Emborg ME. Reframing the Perception of Outliers and Negative Data in Translational Research. Brain Res Bull. 2022 Dec 1:S0361-9230(22)00328-8. 

NOVEMBER 2022

Dumesic DA, Winnett C, Lu G, Grogan TR, Abbott DH, Naik R, Chazenbalk GD. Randomized clinical trial: effect of low-dose flutamide on abdominal adipogenic function in normal-weight women with polycystic ovary syndrome. Fertil Steril. 2022 Nov 15:S0015-0282(22)01745-9.

Harwood OE, Balgeman AJ, Weaver AJ, Ellis-Connell AL, Weiler AM, Erickson KN, Matschke LM, Golfinos AE, Vezys V, Skinner PJ, Safrit JT, Edlefsen PT, Reynolds MR, Friedrich TC, O’Connor SL. Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803. J Virol. 2022 Nov 15:e0142422.

Masood F, Sharma M, Mand D, Nesathurai S, Simmons HA, Brunner K, Schalk DR, Sledge JB, Abdullah HA. A Novel Application of Deep Learning (Convolutional Neural Network) for Traumatic Spinal Cord Injury Classification Using Automatically Learned Features of EMG Signal. Sensors (Basel). 2022 Nov 3;22(21):8455.

OCTOBER 2022

Ellis-Connell AL, Balgeman AJ, Kannal NM, Hansen Chaimson K, Batchenkova A, Safrit JT, O’Connor SL. IL-15 Superagonist N-803 Enhances IFN-γ Production of MAIT Cells in SIV+ Macaques. Infect Immun. 2022 Oct 3:e0025922.

Ellis-Connell AL, Balgeman AJ, Harwood OE, Moriarty RV, Safrit JT, Weiler AM, Friedrich TC, O’Connor SL. Control of Simian Immunodeficiency Virus Infection in Prophylactically Vaccinated, Antiretroviral Treatment-Naive Macaques Is Required for the Most Efficacious CD8 T Cell Response during Treatment with the Interleukin-15 Superagonist N-803. J Virol. 2022 Oct 3:e0118522.

SEPTEMBER 2022

Ziegler TE, Tecot SR, Fernandez-Duque E, Savage A, Snowdon CT. Nonhuman Primate Paternal Care: Species and Individual Differences in Behavior and Mechanisms. Adv Neurobiol. 2022;27:213-238.

lsen ME, Brodsky EK, Oler JA, Riedel MK, Mueller SAL, Vermilyea SC, Metzger JM, Tao Y, Brunner KG, Ahmed AS, Zhang SC, Emborg ME, Kalin NH, Block WF. Real-time trajectory guide tracking for intraoperative MRI-guided neurosurgery. Magn Reson Med. 2022 Sep 21.

Zhao F, Berndsen ZT, Pedreño-Lopez N, Burns A, Allen JD, Barman S, Lee WH, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R, Ward AB, Burton DR, Sok D. Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus. Nat Commun. 2022 Sep 6;13(1):5236.

AUGUST 2022

Seiter DP, Nguyen SM, Morgan TK, Mao L, Dudley DM, O’connor DH, Murphy ME, Ludwig KD, Chen R, Dhyani A, Zhu A, Schotzko ML, Brunner KG, Shah DM, Johnson KM, Golos TG, Wieben O. Ferumoxytol Dynamic Contrast Enhanced Magnetic Resonance Imaging Identifies Altered Placental Cotyledon Perfusion in Rhesus Macaques. Biol Reprod. 2022 Aug 26:ioac168.

Banes GL, Fountain ED, Karklus A, Fulton RS, Antonacci-Fulton L, Nelson JO. Nine out of ten samples were mistakenly switched by The Orang-utan Genome Consortium. Sci Data. 2022 Aug 12;9(1):485. (See also Locke et al, Author Correction: Comparative and demographic analysis of orang-utan genomes, Nature, 12 August 2022.

Doudlah R, Chang TY, Kim B, Sunkara A, Thompson LW, Lowe ME, Rosenberg A. Functional links between sensory representations, choice activity, and sensorimotor associations in parietal cortex. Elife. 2020 Oct 20;9:e57968.

Ramuta MD, Newman CM, Brakefield SF, Stauss MR, Wiseman RW, Kita-Yarbro A, O’Connor EJ, Dahal N, Lim A, Poulsen KP, Safdar N, Marx JA, Accola MA, Rehrauer WM, Zimmer JA, Khubbar M, Beversdorf LJ, Boehm EC, Castañeda D, Rushford C, Gregory DA, Yao JD, Bhattacharyya S, Johnson MC, Aliota MT, Friedrich TC, O’Connor DH, O’Connor SL. SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings. Nat Commun. 2022 Aug 11;13(1):4717.

Schmidt JK, Reynolds MR, Golos TG, Slukvin II. CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection. Retrovirology. 2022 Aug 10;19(1):17. doi: 10.1186/s12977-022-00604-5.PMID: 35948929 Free PMC article. Review.

Raasch LE, Yamamoto K, Newman CM, Rosinski JR, Shepherd PM, Razo E, Crooks CM, Bliss MI, Breitbach ME, Sneed EL, Weiler AM, Zeng X, Noguchi KK, Morgan TK, Fuhler NA, Bohm EK, Alberts AJ, Havlicek SJ, Kabakov S, Mitzey AM, Antony KM, Ausderau KK, Mejia A, Basu P, Simmons HA, Eickhoff JC, Aliota MT, Mohr EL, Friedrich TC, Golos TG, O’Connor DH, Dudley DM. Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus. PLoS Negl Trop Dis. 2022 Aug 4;16(8).

Masilkova M, Boukal D, Ash H, Buchanan-Smith HM, Konečná M. Linking personality traits and reproductive success in common marmoset (Callithrix jacchus). Sci Rep. 2022 Aug 3;12(1):13341.

JULY 2022

Weinfurter JT, D’Souza SS, Matschke LM, Bennett S, Kelnhofer-Millevolte LE, Suknuntha K, Kumar A, Coonen J, Capitini CM, Hematti P, Golos TG, Slukvin II, Reynolds MR. Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques. Sci Rep. 2022 Jul 19;12(1):12345.

Dudley DM, Koenig MR, Stewart LM, Semler MR, Newman CM, Shepherd PM, Yamamoto K, Breitbach ME, Schotzko M, Kohn S, Antony KM, Qiu H, Tunga P, Anderson DM, Guo W, Dennis M, Singh T, Rybarczyk S, Weiler AM, Razo E, Mitzey A, Zeng X, Eickhoff JC, Mohr EL, Simmons HA, Fritsch MK, Mejia A, Aliota MT, Friedrich TC, Golos TG, Kodihalli S, Permar SR, O’Connor DH. Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques. PLoS One. 2022 Jul 14;17(7).

Ikonomidou C, Wang SH, Fuhler NA, Larson S, Capuano S 3rd, Brunner KR, Crosno K, Simmons HA, Mejia AF, Noguchi KK.  Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs. Neurobiol Dis. 2022 Sep;171:105814.

Redinbaugh MJ, Afrasiabi M, Phillips JM, Kambi NA, Mohanta S, Raz A, Saalmann YB. Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness. PLoS Comput Biol. 2022 Jul 11;18(7):e1010294.

Phillips KA, Lopez M, Salmon AB, Ross CN, Abbott DH, Capitanio JP. Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus). J Med Primatol. 2022 Jul 5.

Ball EE, Pesavento PA, Van Rompay KKA, Keel MK, Singapuri A, Gomez-Vazquez JP, Dudley DM, O’Connor DH, Breitbach ME, Maness NJ, Schouest B, Panganiban A, Coffey LL. Zika virus persistence in the male macaque reproductive tract. PLoS Negl Trop Dis. 2022 Jul 5;16(7)

JUNE 2022

Moriarty RV, Rodgers MA, Ellis AL, Balgeman AJ, Larson EC, Hopkins F, Chase MR, Maiello P, Fortune SM, Scanga CA, O’Connor SL. Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis. Microbiol Spectr. 2022 Jun 29;10(3)

Lawrence SP, Elser SE, Torben W, Blair RV, Pahar B, Aye PP, Schiro F, Szeltner D, Doyle-Meyers LA, Haggarty BS, Jordan APO, Romano J, Leslie GJ, Alvarez X, O’Connor DH, Wiseman RW, Fennessey CM, Li Y, Piatak M Jr, Lifson JD, LaBranche CC, Lackner AA, Keele BF, Maness NJ, Marsh M, Hoxie JA. A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection. PLoS Pathog. 2022 Jun 17;18(6):e1010507.

Smith AB, Schill JP, Gordillo R, Gustafson GE, Rhoads TW, Burhans MS, Broman AT, Colman RJ, Scherer PE, Anderson RM. Ceramides are early responders in metabolic syndrome development in rhesus monkeys. Sci Rep. 2022 Jun 15;12(1):9960.

Amato KA, Haddock LA 3rd, Braun KM, Meliopoulos V, Livingston B, Honce R, Schaack GA, Boehm E, Higgins CA, Barry GL, Koelle K, Schultz-Cherry S, Friedrich TC, Mehle A. Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks. Nat Commun. 2022 Jun 14;13(1):3416.

Zinnen AD, Vichich J, Metzger JM, Gambardella JC, Bondarenko V, Simmons HA, Emborg ME.PLoS One. 2022 Jun 10;17(6):e0269190. Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum. PLoS One. 2022 Jun 10;17(6):e0269190.

Croft MA, Peterson J, Smith C, Kiland J, Nork TM, Mcdonald JP, Katz A, Hetzel S, Lütjen-Drecoll E, Kaufman PL. Accommodative movements of the choroid in the optic nerve head region of human eyes, and their relationship to the lens. Exp Eye Res. 2022 Jun 7:109124.

MAY 2022

DuBois M, Tseng A, Francis SM, Haynos AF, Peterson CB, Jacob S. Utility of Downstream Biomarkers to Assess and Optimize Intranasal Delivery of Oxytocin. Pharmaceutics. 31 May 2022.

Harris RA, Raveendran M, Lyfoung DT, Sedlazeck FJ, Mahmoud M, Prall TM, Karl JA, Doddapaneni H, Meng Q, Han Y, Muzny D, Wiseman RW, O’Connor DH, Rogers J. Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus. Gigascience. 2022 May 28;11:giac039.

Ash H, Chang A, Ortiz R, Kulkarni P, Rauch B, Colman R, Ferris C, Ziegler Z. Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus). Behav Brain Res. 2022 May 17;113920.

Halfmann PJ, Kuroda M, Armbrust T, Theiler J, Balaram A, Moreno GK, Accola MA, Iwatsuki-Horimoto K, Valdez R, Stoneman E, Braun K, Yamayoshi S, Somsen E, Baczenas JJ, Mitamura K, Hagihara M, Adachi E, Koga M, McLaughlin M, Rehrauer W, Imai M, Yamamoto S, Tsutsumi T, Saito M, Friedrich TC, O’Connor SL, O’Connor DH, Gordon A, Korber B, Kawaoka Y.  Characterization of the SARS-CoV-2 B.1.621 (Mu) variant. Sci Transl Med. 2022 May 17:eabm4908.

Janaka SK, Snow BJ, Behrens RT, Evans DT. Substitutions in Nef That Uncouple Tetherin and SERINC5 Antagonism Impair Simian Immunodeficiency Virus Replication in Primary Rhesus Macaque Lymphocytes. J Virol. 2022 May 10:e0017622.

Block LN, Schmidt JK, Keuler NS, McKeon MC, Bowman BD, Wiepz GJ, Golos TG. Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts. Sci Rep. 2022 May 5;12(1):7348.

APRIL 2022

Uenishi GI, Jung HS, Slukvin II. Assessment of Endothelial-to-Hematopoietic Transition of Individual Hemogenic Endothelium and Bulk Populations in Defined Conditions. Methods Mol Biol. 2022;2429:103-124.

Kraynak M, Willging MM, Kuehlmann AL, Kapoor AA, Flowers MT, Colman RJ, Levine JE, Abbott DH. Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys. J Endocr Soc. 2022 Apr 22;6(6):bvac063.

D’Souza SS, Kumar A, Maufort J, Weinfurter JT, Raymond M, Strelchenko N, Perrin E, Coonen J, Mejia A, Simmons H, Torbett BE, Reynolds M, Thomson JA, Slukvin I. Assessment of Safety and Immunogenicity of MHC homozygous iPSC-derived CD34+ Hematopoietic Progenitors in a NHP Model. Blood Adv. 2022 Apr 11:bloodadvances.2022006984.

Pomerantz O, Baker KC, Bellanca RU, Bloomsmith MA, Coleman K, Hutchinson EK, Pierre PJ, Weed JL; National Primate Research Centers’ Behavioral Management Consortium. Improving transparency-A call to include social housing information in biomedical research articles involving nonhuman primates. Am J Primatol. 2022 Apr 1:e23378.

MARCH 2022

Dukes NJ, Ash H, de Faria Oliveira G, Sosa ME, Goy RW, Colman RJ, Ziegler TE. Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset fathers, Callithrix jacchus. Horm Behav. 2022 Mar 30;142:105162.

Nicholas RE, Sandstrom K, Anderson JL, Smith WR, Wetzel M, Banerjee P, Janaka SK, Evans DT. KIR3DL05 and KIR3DS02 Recognition of a Nonclassical MHC Class I Molecule in the Rhesus Macaque Implicated in Pregnancy Success. Front Immunol. 2022 Mar 23;13:841136.

D’Souza SS, Kumar A, Weinfurter J, Park MA, Maufort J, Tao L, Kang H, Dettle ST, Golos T, Thomson JA, Reynolds MR, Slukvin I. Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus. Stem Cell Reports. 2022 Mar 17:S2213-6711(22)00136-9.

Gopalakrishnan K, Mishra JS, Ross JR, Abbott DH, Kumar S. Hyperandrogenism diminishes maternal-fetal fatty acid transport by increasing FABP 4-mediated placental lipid accumulation. Biol Reprod. 2022 Mar 31:ioac059.

Little CJ, Haynes WJ, Huang L, Daffada CM, Wolfe KB, Perrin E, Simpson JA, Kropp Schmidt JA, Hinkle HM, Keding LT, Behrens RT, Evans DT, Kaufman DB, Thomson JA, Golos TG, Brown ME. Robust engraftment of fetal nonhuman primate CD34-positive cells in immune-deficient mice. J Leukoc Biol. 2022 Mar 30.

Balasubramanian P, Schaar AE, Gustafson GE, Smith AB, Howell PR, Greenman A, Baum S, Colman RJ, Lamming DW, Diffee GM, Anderson RM. Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice. Elife. 2022 Mar 17;11:e71282.

Terasawa E.  The mechanism underlying the pubertal increase in pulsatile GnRH release in primates. J Neuroendocrinol. 2022 Mar 15:e13119.

Croft MA, Nork TM, Heatley G, McDonald JP, Katz, A, Kaufman P. Intraocular accommodative movements in monkeys; relationship to presbyopia. Exp Eye Res. 2022 Mar 10;109029.

Santika T, Sherman J, Voigt M, Ancrenaz M, Wich SA, Wilson KA, Possingham H, Massingham E, Seaman DJI, Ashbury AM, Azvi TS, Banes GL, Barrow EJ, Burslem DFRP, Delgado RA, Erman A, Fredriksson G, Goossens B, Houghton M, Indrawan TP, Jaya RL, Kanamori T, Knott CD, Leiman A, Liswanto D, Mach M, Marshall AJ, Martin JGA, Midora L, Miller A, Milne S, Morgans C, Nardiyono N, Perwitasari-Farajallah D, Priatna D, Risch R, Riyadi GM, Russon A, Sembiring J, Setiawan E, Sidiq M, Simon D, Spehar S, Struebig MJ, Sumardi I, Tjiu A, Wahyudi R, Yanuar A, Meijaard E. Effectiveness of 20 years of conservation investments in protecting orangutans. Curr Biol. 2022 Mar 9:S0960-9822(22)00315-3.

Clark NM, Janaka SK, Hartman W, Stramer S, Goodhue E, Weiss J, Evans DT, Connor JP. Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infection. PLoS One. 2022 Mar 8;17(3):e0257930. 

Schmidt JK, Jones KM, Van Vleck T, Emborg ME. Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges. Sci Transl Med. 2022 Mar 2;14(634):eabf4879.

FEBRUARY 2022

Zhou R, Bruns CM, Bird IM, Kemnitz JW, Dumesic DA, Abbott DH. Experimentally Induced Hyperinsulinemia Fails to Induce Polycystic Ovary Syndrome-like Traits in Female Rhesus Macaques. Int. J. Mol. Sci. 2022 Feb 27;23(5):2635.

Goy RW, Shrestha HK, Colman RJ, Dukes NJ, Ziegler TE, Kapoor A. Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Feb 25;1195:123150.

Moody JF, Aggarwal N, Dean DC 3rd, Tromp DPM, Kecskemeti SR, Oler JA, Kalin NH, Alexander AL. Neuroimage. 2022 Feb 10:118989. Longitudinal Assessment of Early-Life White Matter Development with Quantitative Relaxometry in Nonhuman Primates.

Pampusch MS, Abdelaal HM, Cartwright EK, Molden JS, Davey BC, Sauve JD, Sevcik EN, Rendahl AK, Rakasz EG, Connick E, Berger EA, Skinner PJ. CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection. PLoS Pathog. 2022 Feb 7;18(2):e1009831.

JANUARY 2022

Goyal A, Gardner M, Mayer BT, Jerome KR, Farzan M, Schiffer JT, Cardozo-Ojeda EF. Estimation of the in vivo neutralization potency of eCD4Ig and conditions for AAV-mediated production for SHIV long-term remission. Sci Adv. 2022 Jan 14;8(2).

Dumesic DA, Padmanabhan V, Chazenbalk GD, Abbott DH. Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation. Reprod Biol Endocrinol. 2022 Jan 10;20(1):12

Eerhart MJ, Reyes JA, Blanton CL, Danobeitia JS, Chlebeck PJ, Zitur LJ, Springer M, Polyak E, Coonen J, Capuano S, D’Alessandro AM, Torrealba J, van Amersfoort E, Ponstein Y, van Kooten C, Burlingham W, Sullivan J, Pozniak M, Zhong W, Yankol Y, Fernandez LA. Complement Blockade in Recipients Prevents Delayed Graft Function and Delays Antibody-mediated Rejection in a Nonhuman Primate Model of Kidney Transplantation. Eerhart MJ, Reyes JA, Blanton CL, Danobeitia JS, Chlebeck PJ, Zitur LJ, Springer M, Polyak E, Coonen J, Capuano S, D’Alessandro AM, Torrealba J, van Amersfoort E, Ponstein Y, van Kooten C, Burlingham W, Sullivan J, Pozniak M, Zhong W, Yankol Y, Fernandez LA. Transplantation. 2022 Jan 1;106(1):60-71.