WNPRC Scientific Journal Articles

References involving Wisconsin National Primate Research Center resources and/or authors are listed courtesy of WNPRC staff and PubMed, National Library of Medicine. If you do not see your publication on this list, please contact us. Please acknowledge NIH ORIP grant number P51OD011106 and the Wisconsin National Primate Research Center in your manuscripts if your research involved the use of WNPRC resources in part or in full.

To access preprints, please search medrxiv and biorxiv and enter Wisconsin National Primate Research Center and other terms (e.g., “Wisconsin National Primate Research Center SARS CoV-2”).

MARCH 2025

Zhang J, Tabima DM, Vereide D, Zeng W, Albano NJ, Lyon S, Nicksic PJ, Shaffrey EC, George RE, Probasco MD, Perrin ES, Xu Y, Brown ME, Stewart R, Chesler NC, Turng LS, Poore SO, Slukvin II, Thomson JA, Maufort JP. Small-diameter artery grafts engineered from pluripotent stem cells maintain 100% patency in an allogeneic rhesus macaque model. Cell Rep Med. 2025 Mar 4:102002. doi: 10.1016/j.xcrm.2025.102002. Epub ahead of print. PMID: 40068684.

Clark JP, Rhoads TW, McIlwain SJ, Polewski MA, Pavelec DM, Colman RJ, Anderson RM. Caloric restriction reprograms adipose tissues in rhesus monkeys. bioRxiv [Preprint]. 2025 Mar 5:2025.03.03.641286. doi: 10.1101/2025.03.03.641286. PMID: 40093109; PMCID: PMC11908232.

Kwon T, Trujillo JD, Carossino M, Machkovech HM, Cool K, Lyoo EL, Singh G, Kafle S, Elango S, Vediyappan G, Wei W, Minor N, Matias-Ferreyra FS, Morozov I, Gaudreault NN, Balasuriya UBR, Hensley L, Diel DG, Ma W, Friedrich TC, Richt JA. Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs. bioRxiv [Preprint]. 2025 Mar 7:2025.03.04.641414. doi: 10.1101/2025.03.04.641414. PMID: 40093138; PMCID: PMC11908241.

Gutkes J, Krabbe NP, Ausderau K, Mohr EL. Macaque models of prenatal and postnatal Zika virus exposure and developmental outcomes. J Pediatric Infect Dis Soc. 2025 Mar 10:piaf024. doi: 10.1093/jpids/piaf024. Epub ahead of print. PMID: 40059782.

Emborg ME, Metzger JM, D’Amour K, Colwell JC, Neumann LC, Zhang A, Federoff HJ. Advantages and challenges of using allogeneic vs. autologous sources for neuronal cell replacement in Parkinson’s disease: insights from non-human primate studies. Brain Res Bull. 2025 Mar 12:111297. doi: 10.1016/j.brainresbull.2025.111297. Epub ahead of print. PMID: 40086764.Trifone C, Richard C, Pagliuzza A, Dufour C,

Metzler LAP, Metzger JM, Gerred KJ, Emborg ME, Kapoor A. Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques. Exp Gerontol. 2025 Mar 21:112736. doi: 10.1016/j.exger.2025.112736. Epub ahead of print. PMID: 40122475.

FEBRUARY 2025

Lemieux A, Clark NM, Janaka SK, Fennessey CM, Keele BE, Fromentin R, Estes JD, Kaufmann DE, Finzi A, Evans DT, Chomont N. Contribution of intact viral genomes persisting in blood and tissues during ART to plasma viral rebound in SHIV-infected rhesus macaques. iScience. 2025 Feb 11;28(3):111998. doi: 10.1016/j.isci.2025.111998. PMID: 40104070; PMCID: PMC11914814.

Li A, Coffey LL, Mohr EL, Raper J, Chahroudi A, Ausderau KK, Aliota MT, Friedrich TC, Mitzey AM, Koenig MR, Golos TG, Jaeger HK, Roberts VHJ, Lo JO, Smith JL, Hirsch AJ, Streblow DN, Newman CM, O’Connor DH, Lackritz EM, Van Rompay KKA, Adams Waldorf KM; Zika Expert Workgroup. Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection. Lancet Microbe. 2025 Feb 20:101030. doi: 10.1016/j.lanmic.2024.101030. Epub ahead of print. PMID: 40024258.

Keding LT, Heselton AR, Ren E, Shaw SA, Koenig MR, Golos TG, Schmidt JK. In vitro differentiation of macaque extravillous trophoblasts in a low oxygen environment. Placenta. 2025 Feb 25;163:16-28. doi: 10.1016/j.placenta.2025.02.014. Epub ahead of print. PMID: 40024139.

Klenchin VA, Clark NM, Keles NK, Capuano S 3rd, Mason R, Gao G, Broman A, Kose E, Immonen TT, Fennessey CM, Keele BF, Lifson JD, Roederer M, Gardner MR, Evans DT. Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy. Sci Immunol. 2025 Feb 28;10(104):eadq4973. doi: 10.1126/sciimmunol.adq4973. Epub 2025 Feb 28. PMID: 40020046.

JANUARY 2025

Kraynak M, Willging MM, Uhlrich DJ, Shapiro RA, Flowers MT, Manning KA, John SD, Williams SM, Henjum LJ, Marrah RC, Yohnk HR, Berg CB, Brunner K, Colman RJ, Alexander AL, Abbott DH, Levine JE. Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity. J Endocr Soc. 2025 Feb 5;9(3):bvaf012. doi: 10.1210/jendso/bvaf012. PMID: 39911518; PMCID: PMC11795203.

Achorn AM, Mulholland MM, Cox CM, Phillips KA, Bennett AJ, Pierre PJ, Sherwood CC, Schapiro SJ, Hopkins WD. Planum Temporale Asymmetries in Primates: A Comparative Study in Great Apes and Monkeys. Am J Biol Anthropol. 2025 Jan;186(1):e25060. doi: 10.1002/ajpa.25060. PMID: 39815716.

Chen HC, Cheng YC, Hsieh ML, Lin PJ, Wissel EF, Steward T, Chang CMC, Coonen J, Hacker TA, Kamp TJ, Hsieh PCH. Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model. NPJ Regen Med. 2025 Jan 15;10(1):2. doi: 10.1038/s41536-025-00390-6. PMID: 39809790.

DECEMBER 2024

Hayes JM, Hayes MR, Friedrichs KR, Simmons HA. Development of criteria to optimize manual smear review of automated complete blood counts using a machine learning model. Vet Clin Pathol. 2024 Dec 5. doi: 10.1111/vcp.13400. Epub ahead of print. PMID: 39638966.

NOVEMBER 2024

Huber HF, Ainsworth HC, Quillen EE, Salmon A, Ross C, Azhar AD, Bales K, Basso MA, Coleman K, Colman R, Darusman HS, Hopkins W, Hotchkiss CE, Jorgensen MJ, Kavanagh K, Li C, Mattison JA, Nathanielsz PW, Saputro S, Scorpio DG, Sosa PM, Vallender EJ, Wang Y, Zeiss CJ, Shively CA, Cox LA. Comparative lifespan and healthspan of nonhuman primate species common to biomedical research. Geroscience. 2024 Nov 25. doi: 10.1007/s11357-024-01421-8. Epub ahead of print. PMID: 39585646.

Wilson RL, Schmidt JK, Davenport BN, Ren E, Keding LT, Shaw SA, Schotzko ML, Antony KM, Simmons HA, Golos TG, Jones HN. Gene therapy in nonhuman primates: a pilot study of maternal, placental and fetal response to non-viral, polymeric nanoparticle delivery of IGF1. Mol Hum Reprod. 2024 Nov 5.

Scholz J, Secreto FJ, Wobig J, Kurian J, Hagen C, Zinnen A, Vu D, Johnson SJ, Cetta F, Qureshi Y, Reams R, Cannon B, Heyer CM, Chang M, Fadra N, Coonen J, Simmons HA, Mejia A, Hayes JM, Basu P, Capuano S, Bondarenko V, Metzger JM, Nelson TJ, Emborg ME. Human Stem Cell-Derived Cardiomyocytes Integrate Into the Heart of Monkeys With Right Ventricular Pressure Overload. Cell Transplant. 2024 Jan-Dec.

OCTOBER 2024

Larson EC, Ellis AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, de Menezes YT, Ameel CL, Fillmore DJ, Pergalske SM, Juno JA, Maiello P, Chishti HB, Lin PL, Godfrey DI, Kent SJ, Pellicci DG, Ndhlovu LC, O’Connor SL, Scanga CA. Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance. Infect Immun. 2024 Oct 30.

Anderson JL, Sandstrom K, Klenchin VA, Evans DT. Rhesus Macaque Killer Cell Ig-like Receptor Domain 0 Glycans Impact Surface Expression and Ligand Specificity. J Immunol. 2024 Oct 28.

Snow BJ, Keles NK, Grunst MW, Janaka SK, Behrens RT, Evans DT. Potent broadly neutralizing antibodies mediate efficient antibody-dependent phagocytosis of HIV-infected cells. PLoS Pathog. 2024 Oct 28.

Rosen BC, Sawatzki K, Ricciardi MJ, Smith E, Golez I, Mauter JT, Pedreño-López N, Yrizarry-Medina A, Weisgrau KL, Vosler LJ, Voigt TB, Louw JJ, Tisoncik-Go J, Whitmore LS, Panayiotou C, Ghosh N, Furlott JR, Parks CL, Desrosiers RC, Lifson JD, Rakasz EG, Watkins DI, Gale M Jr. Acute-phase innate immune responses in SIVmac239-infected Mamu-B*08+ Indian rhesus macaques may contribute to the establishment of elite control. Front Immunol. 2024 Oct 22.

SEPTEMBER 2024

Kheirkhah AH, Habibi S, Yousefi MH, Mehri S, Ma B, Saleh M, Kavianpour M. Finding potential targets in cell-based immunotherapy for handling the challenges of acute myeloid leukemia. Front Immunol. 2024 Sep 30.

Schmidt JK, Wilson RL, Davenport BN, Hacker TA, Fitz C, Simmons HA, Schotzko ML, Golos TG, Jones HN. Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque. Placenta. 2024 Sep 20.

Dumesic DA, Rasouli MA, Katz JD, Lu GG, Dharanipragada D, Turcu AF, Grogan TR, Flores KE, Magyar CE, Abbott DH, Chazenbalk GD. The Subcutaneous Adipose Microenvironment as a Determinant of Body Fat Development in Polycystic Ovary Syndrome. J Endocr Soc. 2024 Sep 17.

Emborg ME, Gambardella JC, Zhang A, Federoff HJ. Autologous vs heterologous cell replacement strategies for Parkinson disease and other neurologic diseases. Handb Clin Neurol. 2024;205:41-56. 

Mulholland MM, Whitham W, Berkey M, Pytka LM, Pierre P, Hopkins WD. Implementation of automated cognitive testing systems for socially housed rhesus (Macaca mulatta) and squirrel (Saimiri spp.) monkeys: Age differences in learning. J Comp Psychol. 2024 Sep 9.

AUGUST 2024

Huber HF, Ainsworth HC, Quillen E, Salmon A, Ross C, Azhar AD, Bales K, Basso MA, Coleman K, Colman R, Darusman HS, Hopkins W, Hotchkiss CE, Jorgensen M, Kavanagh K, Li C, Mattison JA, Nathanielsz PW, Saputro S, Scorpio D, Sosa PM, Vallender E, Wang Y, Zeiss C, Shively C, Cox LA. Comparative lifespan and healthspan of nonhuman primate species common to biomedical research. bioRxiv [Preprint]. 2024 Aug 6.

JULY 2024

Emborg ME, Mancinelli A, Colwell JC, Zinnen AD, Pape B, Brunner K, Bondarenko V, Fitz C, Coonen J, Menna V, Fuchs K, Schultz-Darken N, Simmons HA, Tran H, Larson P, Olsen M, Hurley S, Bratt-Leal AM, Wirth E, Metzger JM. Preclinical evaluation of transaxial intraputaminal trajectory for enhanced distribution of grafted cells in Parkinson’s disease. J Neurosurg. 2024 Jul 26.

Larson EC, Ellis AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, de Menezes YT, Ameel CL, Fillmore DJ, Pergalske SM, Juno JA, Maiello P, Chishti HB, Lin PL, Godfrey DI, Kent SJ, Pellicci DG, Ndhlovu LC, O’Connor SL, Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance. Scanga CA. bioRxiv [Preprint]. 2024 Jul 23.

Sekulovski N, Wettstein JC, Carleton AE, Juga LN, Taniguchi LE, Ma X, Rao S, Schmidt JK, Golos TG, Lin CW, Taniguchi K. Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification. Elife. 2024 Jul 25.

Sekulovski N, Carleton AE, Rengarajan AA, Lin CW, Juga LN, Whorton AE, Schmidt JK, Golos TG, Taniguchi K.bioRxiv [Preprint]. 2024 Jul 12Sekulovski N, Carleton AE, Rengarajan AA, Lin CW, Juga LN, Whorton AE, Schmidt JK, Golos TG, Taniguchi K. Temporally resolved single cell transcriptomics in a human model of amniogenesis. bioRxiv [Preprint]. 2024 Jul 12.

Wang J, Wang M, Moshiri A, Harris RA, Raveendran M, Nguyen T, Kim S, Young L, Wang K, Wiseman R, O’Connor DH, Johnson Z, Martinez M, Montague MJ, Sayers K, Lyke M, Vallender E, Stout T, Li Y, Thomasy SM, Rogers J, Chen R. Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models. Nat Commun. 2024 Jul 5.

JUNE 2024

Abbott DH, Hutcherson BA, Dumesic DA. Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome? Semin Reprod Med. 2024 Jun 22.

Klenchin VA, Clark NM, Keles NK, Capuano S, Mason R, Gao G, Broman A, Kose E, Immonen TT, Fennessey CM, Keele BF, Lifson JD, Roederer M, Gardner MR, Evans DT. Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy. bioRxiv [Preprint]. 2024 Jun 3.

MAY 2024

Skalski HJ, Arendt AR, Harkins SK, MacLachlan M, Corbett CJM, Goy RW, Kapoor A, Hostetter G, Chandler RL. Key Considerations for Studying the Effects of High-Fat Diet on the Nulligravid Mouse Endometrium. J Endocr Soc. 2024 May 25.

Whyte CJ, Redinbaugh MJ, Shine JM, Saalmann YB. Thalamic contributions to the state and contents of consciousness. Neuron. 2024 May 15.

Egbert RJ, Basu P, Refsal KR, Petroff MG, Petroff BK. Changes in thyroid hormone concentrations over time in dogs with autoimmune thyroiditis. Am J Vet Res. 2024 May 4.

Redinbaugh MJ, Saalmann YB.  Contributions of Basal Ganglia Circuits to Perception, Attention, and Consciousness. Cogn Neurosci. 2024 May 2.

APRIL 2024

Svenson Dvm Mph EL, Coonen Dvm Daclam J, Svenson Md Ms Dabp Dabem JE, Simmons Dvm Dacvp HA, Hayes Bs JM, Capuano Iii Dvm Daclam S. An Epidemiologic Study of Bacterial Culture and Antibiotic Susceptibility Analyses in Captive Macaques and Marmosets at the Wisconsin National Primate Research Center. J Am Assoc Lab Anim Sci. 2024 Apr 22.

Prall TM, Karl JA, Varghese JM, Baker DA, Minor NR, Raveendran M, Harris RA, Rogers J, Wiseman RW, O’Connor DH. Complete Genomic Assembly of Mauritian Cynomolgus Macaque Killer Ig-like Receptor and Natural Killer Group 2 Haplotypes. J Immunol. 2024 Apr 19.

Croft MA, Mcdonald JP, Kiland J, Mattison JA, Roth GS, Ingram D, Kaufman PL. Sex as a risk factor regarding presbyopia in the rhesus monkey. PLoS One. 2024 Apr 18.

Montgomery KE, Basha M, Nyholm L, Smith C, Ananiev G, Fedorov A, Kapoor A, Brown R, Capitini C, Kwekkeboom K. Exploring Inflammation and Stress as Biological Correlates of Symptoms in Children With Advanced Cancer: A Longitudinal Feasibility Study. J Pediatr Hematol Oncol Nurs. 2024 Apr 8.

Chanana V, Zafer D, Kintner DB, Chandrashekhar JH, Eickhoff J, Ferrazzano PA, Levine JE, Cengiz P. TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury. Biol Sex Differ. 2024 Apr 2.

Mansournejad S, Mehrabi M, Yari R, Saleh M. Influence of Different Glucose Concentrations on the Expression of miR-29c-3p microRNA in Mesenchymal Stem Cells. Int J Hematol Oncol Stem Cell Res. 2024 Apr 1.

MARCH 2024

Oliveira GF, Nguyen AT, Carreras-Simons L, Niepsuj T, Gadelhak SH, Johnson AK, Abdalla A, Lev E, Torres Román SG, Fuchs SN, Jorgensen JS, Farhat WA, Auger AP. Puberty blocker, leuprolide, reduces sex differences in rough-and-tumble play and anxiety-like behavior in juvenile rats. Endocrinology. 2024 Mar 29.

Koenig MR, Vazquez J, Leyva Jaimes FB, Mitzey AM, Stanic AK, Golos TG. Decidual leukocytes respond to African lineage Zika virus infection with mild anti-inflammatory changes during acute infection in rhesus macaques. Front Immunol. 2024 Mar 7.

Sekulovski N, Wettstein JC, Carleton AE, Juga LN, Taniguchi LE, Ma X, Rao S, Schmidt JK, Golos TG, Lin CW, Taniguchi K. Temporally resolved early BMP-driven transcriptional cascade during human amnion specification. bioRxiv [Preprint]. 2024 Mar 6.

FEBRUARY 2024

Lim SY, Lee J, Osuna CE, Vikhe P, Schalk DR, Chen E, Fray E, Kumar M, Schultz-Darken N, Rakasz E, Capuano S, Ladd RA, Gil HM, Evans DT, Jeng EK, Seaman M, Martin M, Van Dorp C, Perelson AS, Wong HC, Siliciano JD, Siliciano R, Safrit JT, Nixon DF, Soon-Shiong P, Nussenzweig M, Whitney JB. Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques. Science. 2024 Feb 29.

Giese MA, Bennin DA, Schoen TJ, Peterson AN, Schrope JH, Brand J, Jung HS, Keller NP, Beebe DJ, Dinh HQ, Slukvin II, Huttenlocher A.J. PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function. Leukoc Biol. 2024 Feb 28.

Gerred K, Kapoor A. A fit-for-purpose validation of a commercial radioimmunoassay for measurement of human peripheral oxytocin. Biochem Biophys Rep. 2024 Feb 26.

Vazquez J, Mohamed MA, Banerjee S, Keding LT, Koenig MR, Leyva-Jaimes F, Fisher RC, Bove EM, Golos TG, Stanic AK. Corrigendum: Deciphering decidual leukocyte traffic with serial intravascular staining. Front Immunol. 2024 Feb 26.

Chen R, Seiter D, Keding LT, Vazquez J, Antony KM, Simmons HA, Basu P, Mejia AF, Johnson KM, Stanic AK, Liu RY, Shah DM, Golos TG, Wieben O. Cotyledon-Specific Flow Evaluation of Rhesus Macaque Placental Injury Using Ferumoxytol Dynamic Contrast-Enhanced MRI. J Magn Reson Imaging. 2024 Feb 20.

Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Ameel CL, Jauro S, Tomko JA, Kracinovsky KB, Maiello P, Borish HJ, White AG, Klein E, Bucsan AN, Darrah PA, Seder RA, Roederer M, Lin PL, Flynn JL, O’Connor SL, Scanga CA. Author Correction: Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis. Nat Microbiol. 2024 Feb 14.

Scott AM, Banes GL, Setiadi W, Saragih JR, Susanto TW, Mitra Setia T, Knott CD. Flanged males have higher reproductive success in a completely wild orangutan population. PLoS One. 2024 Feb 9.

JANUARY 2024

Little CJ, Kim SC, Fechner JH, Post J, Coonen J, Chlebeck P, Winslow M, Kobuzi D, Strober S, Kaufman DB.Front Immunol. 2024 Jan 22;15:1343616. Early allogeneic immune modulation after establishment of donor hematopoietic cell-induced mixed chimerism in a nonhuman primate kidney transplant model. Front Immunol. 2024 Jan 22.

Vazquez J, Mohamed MA, Banerjee S, Keding LT, Koenig MR, Leyva Jaimes F, Fisher RC, Bove EM, Golos TG, Stanic AK. Deciphering decidual leukocyte traffic with serial intravascular staining. Front Immunol. 2024 Jan 10.

Grunst MW, Gil HM, Grandea AG 3rd, Snow BJ, Andrabi R, Nedellec R, Burton I, Clark NM, Janaka SK, Keles NK, Moriarty RV, Weiler AM, Capuano S 3rd, Fennessey CM, Friedrich TC, O’Connor SL, O’Connor DH, Broman AT, Keele BF, Lifson JD, Hangartner L, Burton DR, Evans DT. Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge. PLoS Pathog. 2024 Jan 22.

Afhami S, Adibimehr A, Mousavi SA, Vaezi M, Montazeri M, Salehi M, Meidani M, Saleh M, Ahmadikia K, Roilides E, Maertens J, Alijani N. Rate, Risk Factors, and Outcomes of Invasive Fungal Infections in Patients with Hematologic Malignancies. Int J Hematol Oncol Stem Cell Res. 2024 Jan 1.