Igor Slukvin, PhD

OTHER WEB PAGES

Pathology and Laboratory Medicine Cell Reports feature
Stem Cell & Regenerative Medicine Center

ALIGNED RESEARCH FOCUS

Regenerative medicine, stem cells

ORGAN SYSTEM/DISEASE FOCUS

Hematopoietic and vascular system/ blood cancer therapies

RESEARCH DESCRIPTION

The main focus of research in my lab is to significantly advance the clinical use of stem cells through development of novel sources of hematopoietic stem cells, mature blood cells, mesenchymal and endothelial progenitors for transplantation, transfusion and cancer immunotherapy. We use integrative approaches, including genomics, proteomics and bioinformatics, to achieve the outlined goals and to understand important cellular and molecular events leading to mesoderm and blood cell development and diversification. We already developed a very efficient system for hematopoietic and endothelial differentiation of hES and iPS cells, and directed differentiation of hES cells toward red blood cells, dendritic cells, macrophages, osteoclasts and granulocytes. In addition, we defined the major cellular pathways leading to formation of blood cells and identified several novel hematoendothelial, hematopoietic and mesenchymal progenitors. Through comparative analysis of transcriptome and engraftment properties of these novel progenitors and fetal primitive blood cells as well as employing loss-of- and gain-on-function and lineage-tracing experiments, we expect to gain fundamental insights into molecular mechanisms leading to blood and endothelial cell development. These studies could ultimately revolutionize cellular therapies for blood cancer, hereditary blood and cardiovascular disease.

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