OTHER WEB PAGES
ALIGNED RESEARCH FOCUS
Nutrition and aging; reproductive hormones and energy balance; metabolic syndrome
ORGAN SYSTEM/DISEASE FOCUS
Age-related pathology, obesity, type 2 diabetes mellitus, endometriosis
My research career spans more than three decades. Early work focused on the effects of reproductive conditions and gonadal hormones on regulation of energy balance and on the influence of maternal nutrition and metabolism on fetal development. I have also studied obesity and blood glucose regulation. For the past 20-plus years, much of my research has focused on the effects of moderate calorie restriction on the course of aging. Rhesus macaques have been used for most of these studies. As I have taken on administrative roles in the last 15 years, I have coordinated projects in a variety of disciplines and promoted interdisciplinary and translational programs, as well as informatics projects (e.g., Primate Aging Database, Linking Animal Models to Human Disease Initiative and Primate Portal). I am currently involved in the NIH program on clinical and translational science (CTSA program in NIH/NCATS) both locally and nationally and in the Institute of Laboratory Animal Research (ILAR) of the National Academies, particularly in the development of the International Primate Plan to optimize the use and care of nonhuman primates in research.