Shelby O’Connor’s email
OTHER WEB PAGES
ALIGNED RESEARCH FOCUS
ORGAN SYSTEM/DISEASE FOCUS
HIV/AIDS, Tuberculosis, co-infections
My research lab is interested in understanding the host immune response to HIV and the effect that HIV-infection has on host immunity to other pathogens. HIV+ immunocompromised individuals cannot mount robust immune responses like individuals who are otherwise healthy. We use nonhuman primates with defined host MHC genetics to understand key factors of immunity against SIV, a virus closely related to HIV. In addition, we are using nonhuman primates to better understand the role of host genetics in containment of Mycobacterium tuberculosis (Mtb) and the factors that contribute to latent reactivation of Mtb in macaques co-infected with SIV.