Primate Center References 2018


*Kumar A, Lee JH, Suknuntha K, D’Souza SS, Thakur AS, Slukvin II. NOTCH Activation at the Hematovascular Mesoderm Stage Facilitates Efficient Generation of T Cells with High Proliferation Potential from Human Pluripotent Stem Cells. J Immunol. 2018 Dec 21.

*Haj AK, Arbanas JM, Yamniuk AP, Karl JA, Bussan HE, Drinkwater KY, Graham ME, Ericsen AJ, Prall TM, Moore K, Cheng L, Gao M, Graziano RF, Loffredo JT, Wiseman RW, O’Connor DH. Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing. J Immunol. 2019 Jan 1;202(1):151-159. Epub 2018 Dec 10.

*Buechler C, Semler M, Baker DA, Newman C, Cornish JP, Chavez D, Guerra B, Lanford R, Brasky K, Kuhn JH, Johnson RF, O’Connor DH, Bailey AL. Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus. Viruses. 2018 Dec.

*Martins MA, Gonzalez-Nieto L, Shin YC, Domingues A, Gutman MJ, Maxwell HS, Magnani DM, Ricciardi MJ, Pedreño-Lopez N, Bailey VK, Altman JD, Parks CL, Allison DB, Ejima K, Rakasz EG, Capuano S 3rd, Desrosiers RC, Lifson JD, Watkins DI. Vaccine-induced T-cell responses do not predict the rate of acquisition after repeated intrarectal SIVmac239 challenges in Mamu-B*08+ rhesus macaques. J Virol. 2018 Dec 12. [Epub ahead of print]

*Ziegler TE, Kapoor A, Binkley NC, Rice KS, Rogers J, Jolly CJ, Phillips-Conroy JE. Comparison of vitamin D metabolites in wild and captive baboons. Am J Primatol. 2018 Dec;80(12).

*Fisch SC, Nikou AF, Wright EA, Phan JD, Leung KL, Grogan TR, Abbott DH, Chazenbalk GD, Dumesic DA. Precocious subcutaneous abdominal stem cell development to adipocytes in normal-weight women with polycystic ovary syndrome. Fertil Steril. 2018 Dec;110(7):1367-1376.


*Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity. 2018 Nov 29. [Epub ahead of print]

*Slukvin II, Uenishi GI. Arterial Identity Of Hemogenic Endothelium: A Key To Unlock Definitive Hematopoietic Commitment In hPSC Cultures. Exp Hematol. 2018 Nov 27 [Epub ahead of print]

*Reyes L, Golos TG. Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy. Front Immunol. 2018 Nov 15;9:2628. eCollection. Review. (This work was supported by a WNPRC Pilot Research Project Grant.)

*Weisgrau KL, Vosler LJ, Pomplun NL, Hayes JM, Simmons HA, Friedrichs KR, Rakasz EG. Neutrophil progenitor populations of rhesus macaques. J Leukoc Biol. 2018 Nov 5. [Epub ahead of print]]


*Strier KB, Ziegler TE. From the field to the lab: Muriqui endocrinology from a collaborative perspective. Am J Primatol. 2018 Oct 30:e22928. [Epub ahead of print]

*Ludwig KD, Fain SB, Nguyen SM, Golos TG, Reeder SB, Bird IM, Shah DM, Wieben OE, Johnson KM. Perfusion of the placenta assessed using arterial spin labeling and ferumoxytol dynamic contrast enhanced magnetic resonance imaging in the rhesus macaque. Magn Reson Med. 2018 Oct 25. [Epub ahead of print]

*Ellis-Connell AL, Kannal NM, Balgeman AJ, O’Connor SL. Characterization of major histocompatibility complex-related molecule 1 sequence variants in non-human primates. Immunogenetics. 2018 Oct 23. doi: 10.1007/s00251-018-1091-1. [Epub ahead of print]

*Kohn LAP, Lubach GR. Postcranial skeletal differences in free-range and captive-born primates. Anat Rec (Hoboken). 2018 Oct 12. [Epub ahead of print].

*Kumar S, Gordon GH, Abbott DH, Mishra JS. Androgens in maternal vascular and placental function: implications for preeclampsia pathogenesis. Reproduction. 2018 Oct 16;156(5):R155-R167.

*Park MA, Jung HS, Slukvin I. Genetic Engineering of Human Pluripotent Stem Cells Using PiggyBac Transposon System. Curr Protoc Stem Cell Biol. 2018 Oct 3:e63. [Epub ahead of print]

*Sarkar M, Lai JC, Sawinski D, Ziegler TE, Cedars M, Forde KA. Sex Hormone Levels by Presence and Severity of Cirrhosis in Women With Chronic Hepatitis C Virus (HCV) Infection. J Viral Hepat. 2018 Oct 19.  [Epub ahead of print]

**Schmitt K, Curlin J, Kumar DM, Remling-Mulder L, Feely S, Stenglein M, O’Connor S, Marx P, Akkina R. SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2. J Med Primatol. 2018 Oct;47(5):298-301.

*Sison SL, Vermilyea SC, Emborg ME, Ebert AD. Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson’s Disease-Relevant Phenotypes. Curr Neurol Neurosci Rep. 2018 Oct 4;18(12):84. Review.


*Banerjee P, Ries M, Janaka SK, Grandea AG 3rd, Wiseman R, O’Connor DH, Golos TG, Evans DT. Diversification of Bw4 Specificity and Recognition of a Nonclassical MHC Class I Molecule Implicated in Maternal-Fetal Tolerance by Killer Cell Ig-like Receptors of the Rhesus Macaque. J Immunol. 2018 Sep 19. [Epub ahead of print]

*Rodgers MA, Ameel C, Ellis-Connell AL, Balgeman AJ, Maiello P, Barry GL, Friedrich TC, Klein E, O’Connor SL, Scanga CA. Pre-existing SIV Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques.Infect Immun. 2018 Sep 17. [Epub ahead of print]


**Mitchell SJ, Bernier M, Mattison JA, Aon MA, Kaiser TA, Anson RM, Ikeno Y, Anderson RM, Ingram DK, de Cabo R. Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories. Cell Metab. 2018 Aug 24. [Epub ahead of print]

*Li H, Hai Y, Lim SY, Toledo N, Crecente-Campo J, Schalk D, Li L, Omange RW, Dacoba TG, Liu LR, Kashem MA, Wan Y, Liang B, Li Q, Rakasz E, Schultz-Darken N, Alonso MJ, Plummer FA, Whitney JB, Luo M. Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques. PLoS One. 2018 Aug 28;13(8). eCollection 2018.

*Janaka SK, Tavakoli-Tameh A, Neidermyer WJ, Serra-Moreno R, Hoxie JA, Desrosiers RC, Johnson RP, Lifson JD, Wolinsky SM, Evans DT.  Polymorphisms in Rhesus Macaque Tetherin are Associated with Differences in Acute Viremia in SIV ΔNef-Infected Animals. Janaka SK, Tavakoli-Tameh A, Neidermyer WJ, Serra-Moreno R, Hoxie JA, Desrosiers RC, Johnson RP, Lifson JD, Wolinsky SM, Evans DT. J Virol. 2018 Aug 22. [Epub ahead of print]

*Sutton MS, Ellis-Connell A, Moriarty RV, Balgeman AJ, Gellerup D, Barry G, Weiler AM, Friedrich TC, O’Connor SL. Acute-phase CD4+ T cell responses targeting invariant viral regions are associated with control of live-attenuated simian immunodeficiency virus. J Virol. 2018 Aug 15. [Epub ahead of print]

*Saltzman W, Abbott DH, Binkley N, Colman RJ. Maintenance of bone mass despite estrogen depletion in female common marmoset monkeys (Callithrix jacchus).Am J Primatol. 2018 Aug 14:e22905. [Epub ahead of print]

JULY 2018

*Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Sánchez-San Martín C, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale Jr M, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano III SV, Simmons HA, Mejia A, Friedrich TC, Golos TG and O’Connor DH. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nature Medicine. July 2, 2018.

*Fox AS, Oler JA, Birn RM, Shackman AJ, Alexander AL, Kalin NH. Functional connectivity within the primate extended amygdala is heritable and associated with early-life anxious temperament. J Neurosci. 2018 Jul 30. pii: 0102-18. [Epub ahead of print]

*Garcia JP, Keen KL, Kenealy BP, Seminara SB, Terasawa E. Role of Kisspeptin and Neurokinin B Signaling in Male Rhesus Monkey Puberty. Endocrinology. 2018 Jul 5. [Epub ahead of print]

*Kapoor A, Schultz-Darken N, Ziegler TE. Radiolabel validation of cortisol in the hair of rhesus monkeys. Psychoneuroendocrinology. 2018 Jul 19;97:190-195. [Epub ahead of print] (This work was supported by a WNPRC Pilot Research Project Grant.)

*Kraynak M, Colman RJ, Flowers MT, Abbott DH, Levine JE. Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys. Int J Obes (Lond). 2018 Jul 18. [Epub ahead of print]

*Metzger JM, Moore CF, Boettcher CA, Brunner KG, Fleddermann RA, Matsoff HN, Resnikoff HA, Bondarenko V, Kamp TJ, Hacker TA, Barnhart TE, Lao PJ, Christian BT, Nickles RJ, Gallagher CL, Holden JE, Emborg ME. In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration. NPJ Parkinsons Dis. 2018 Jul 13;4:22. eCollection 2018.

*Muniz CP, Cavalcante LTF, Dudley DM, Pissinatti A, O’Connor DH, Santos AF, Soares MA. First Complete Genome Sequence of a Simian Foamy Virus Infecting the Neotropical PrimateBrachyteles arachnoides. Microbiol Resour Announc. 2018 Jul 19;7(2). eCollection 2018 Jul.

*Slukvin II, Kumar A. The mesenchymoangioblast, mesodermal precursor for mesenchymal and endothelial cells. Cell Mol Life Sci. 2018 Jul 10. [Epub ahead of print] Review.

JUNE 2018

*Dutton MB, Pierre PJ, Bailoo JD, Warkins E, Michel GF, Bennett AJ. A model quantitative assessment tool for nonhuman primate environmental enrichment plans. June 8, 2018.

*Martins MA, Tully DC, Pedreño-Lopez N, von Bredow B, Pauthner MG, Shin YC, Yuan M, Lima NS, Bean DJ, Gonzalez-Nieto L, Domingues A, Gutman MJ, Maxwell HS, Magnani DM, Ricciardi MJ, Bailey VK, Altman JD, Burton DR, Ejima K, Allison DB, Evans DT, Rakasz EG, Parks CL, Bonaldo MC, Capuano S 3rd, Lifson JD, Desrosiers RC, Allen TM, Watkins DI. Mamu-B*17+ rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication. J Virol. 2018 Jun 6. [Epub ahead of print]

*Shin YC, Bischof GF, Lauer WA, Gonzalez-Nieto L, Rakasz EG, Hendricks GM, Watkins DI, Martins MA, Desrosiers RC. A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products. PLoS Pathog. 2018 Jun 18;14(6):e1007143. eCollection 2018 Jun.

*Weger-Lucarelli J, Garcia SM, Rückert C, Byas A, O’Connor SL, Aliota MT, Friedrich TC, O’Connor DH, Ebel GD. Using barcoded Zika virus to assess virus population structure in vitro and in Aedes aegypti mosquitoes. Virology. 2018 Jun 20;521:138-148. [Epub ahead of print]

MAY 2018

*Kang H, Mesquitta WT, Jung HS, Moskvin OV, Thomson JA, Slukvin II.  GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition. Stem Cell Reports. 2018 May 24. [Epub ahead of print]

*Park MA, Kumar A, Jung HS, Uenishi G, Moskvin OV, Thomson JA, Slukvin II. Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential. Cell Rep. 2018 May 22;23(8):2467-2481.

*Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II. NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nat Commun. 2018 May 8;9(1):1828.

*Ziegler TE. Measuring peripheral oxytocin and vasopressin in nonhuman primates. Am J Primatol. 2018 May 14:e22871. [Epub ahead of print] Review.

APRIL 2018

**Magnani DM, Rogers TF, Maness NJ, Grubaugh ND, Beutler N, Bailey VK, Gonzalez-Nieto L, Gutman MJ, Pedreño-Lopez N, Kwal JM, Ricciardi MJ, Myers TA, Julander JG, Bohm RP, Gilbert MH, Schiro F, Aye PP, Blair RV, Martins MA, Falkenstein KP, Kaur A, Curry CL, Kallas EG, Desrosiers RC, Goldschmidt-Clermont PJ, Whitehead SS, Andersen KG, Bonaldo MC, Lackner AA, Panganiban AT, Burton DR, Watkins DI. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques. Nat Commun. 2018 Apr 24;9(1):1624.

*Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O’Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, Vanderford TH, Fair D, Earl E, Feczko E, Styner M, Jean SM, Cohen JK, Silvestri G, Johnson RP, O’Connor DH, Wrammert J, Suthar MS, Sanchez MM, Alvarado MC, Chahroudi A. Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques. Sci Transl Med. 2018 Apr 4;10(435).

*Schmidt JK, Block LN, Golos TG. Defining the rhesus macaque placental miRNAome: Conservation of expression of placental miRNA clusters between the macaque and human. Placenta. 2018 May;65:55-64. Epub 2018 Apr 11.

*Terasawa E, Garcia JP, Seminara SB, Keen KL.  Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates. Front Endocrinol (Lausanne). 2018 Apr 6;9:148.

*Terasawa E. Neuroestradiol in regulation of GnRH release. Horm Behav. 2018 Apr 4. [Epub ahead of print] Review.

MARCH 2018

*Aliota MT, Dudley DM, Newman CM, Weger-Lucarelli J, Stewart LM, Koenig MR, Breitbach ME, Weiler AM, Semler MR, Barry GL, Zarbock KR, Haj AK, Moriarty RV, Mohns MS, Mohr EL, Venturi V, Schultz-Darken N, Peterson E, Newton W, Schotzko ML, Simmons HA, Mejia A, Hayes JM, Capuano S 3rd, Davenport MP, Friedrich TC, Ebel GD, O’Connor SL, O’Connor DH. Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics. PLoS Pathog. 2018 Mar 28;14(3):e1006964. [Epub ahead of print]

*Chang TA, Bondarenko GI, Gerami-Naini B, Drenzek JG, Durning M, Garthwaite MA, Schmidt JK, Golos TG. Trophoblast differentiation, invasion and hormone secretion in a three-dimensional in vitro implantation model with rhesus monkey embryos. Reprod Biol Endocrinol. 2018 Mar 16;16(1):24.

*D’Souza SS, Kumar A, Slukvin II. Functional Heterogeneity of Endothelial Cells Derived from Human Pluripotent Stem Cells. Stem Cells Dev. 2018 Mar 27. [Epub ahead of print]

*Haran KP, Hajduczki A, Pampusch MS, Mwakalundwa G, Vargas-Inchaustegui DA, Rakasz EG, Connick E, Berger EA, Skinner PJ. Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication. Front Immunol. 2018 Mar 20;9:492. eCollection 2018.

*Kempton SJ, Israel JS, Capuano Iii S, Poore SO. Repair of a Large Ventral Hernia in a Rhesus Macaque (Macaca mulatta) by Using an Abdominal Component Separation Technique. Comp Med. 2019 Mar 1;68(2):177-181.

*Morgan RA, Karl JA, Bussan HE, Heimbruch KE, O’Connor DH, Dudley DM. Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center. Immunogenetics. 2018 Mar 28. [Epub ahead of print]

*Richard J, Prévost J, Baxter AE, von Bredow B, Ding S, Medjahed H, Delgado GG, Brassard N, Stürzel CM, Kirchhoff F, Hahn BH, Parsons MS, Kaufmann DE, Evans DT, Finzi A. Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses. MBio. 2018 Mar 20;9(2).

*Rhoads TW, Burhans MS, Chen VB, Hutchins PD, Rush MJP, Clark JP, Stark JL, McIlwain SJ, Eghbalnia HR, Pavelec DM, Ong IM, Denu JM, Markley JL, Coon JJ, Colman RJ, Anderson RM. Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys. Cell Metab. 2018 Mar 6;27(3):677-688.e5.

*Rosado-Mendez IM, Carlson LC, Woo KM, Santoso AP, Guerrero QW, Palmeri ML, Feltovich H, Hall TJ. Quantitative assessment of cervical softening during pregnancy in the Rhesus macaque with shear wave elasticity imaging. Phys Med Biol. 2018 Mar 8. [Epub ahead of print]

*Suknuntha K, Tao L, Brok-Volchanskaya V, D’Souza SS, Kumar A, Slukvin I. Optimization of Synthetic mRNA for Highly Efficient Translation and its Application in the Generation of Endothelial and Hematopoietic Cells from Human and Primate Pluripotent Stem Cells. Stem Cell Rev. 2018 Mar 8. [Epub ahead of print]

*Vermilyea SC, Emborg ME. The role of nonhuman primate models in the development of cell-based therapies for Parkinson’s disease. J Neural Transm (Vienna). 2018 Mar;125(3):365-384. Epub 2017 Mar 22. Review.


*Bissel SJ, Gurnsey K, Jedema HP, Smith NF, Wang G, Bradberry CW, Wiley CA. Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. Retrovirology. 2018 Feb 1;15(1):17.

*Guedikian AA, Lee AY, Grogan TR, Abbott DH, Largaespada K, Chazenbalk GD, Dumesic DA. Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome. Fertil Steril. 2018 Feb 7. [Epub ahead of print]

*Jones CA, Duffy MK, Hoffman SA, Schultz-Darken NJ, Braun KM, Ciucci MR, Emborg ME. Vocalization development in common marmosets for neurodegenerative translational modeling. Neurol Res. 2018 Feb 19:1-9. [Epub ahead of print]

*Riesche L, Tardif SD, Ross CN, deMartelly VA, Ziegler T, Rutherford JN. The Common Marmoset Monkey: Avenues for Exploring the Prenatal, Placental and Postnatal Mechanisms in Developmental Programming of Pediatric Obesity. Am J Physiol Regul Integr Comp Physiol. 2018 Feb 7. [Epub ahead of print]

*Seth N, Simmons HA, Masood F, Graham WA, Rosene DL, Westmoreland SV, Cummings SM, Gwardjan B, Sejdic E, Hoggatt AF, Schalk DR, Abdullah HA, Sledge JB, Nesathurai S. Model of Traumatic Spinal Cord Injury for Evaluating Pharmacologic Treatments in Cynomolgus Macaques. Comp Med. 2018 Feb 1;68(1):63-73.

*Vermilyea SC, Emborg M. In Vitro Modeling of Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S-Mediated Parkinson’s Disease Pathology. Stem Cells Dev. 2018 Feb 5. [Epub ahead of print]


*Aktas Z, Rao H, Slauson SR, Gabelt BT, Larsen IV, Sheridan RTC, Herrnberger L, Tamm ER, Kaufman PL, Brandt CR. Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):298-310.

**Eudailey JA, Dennis ML, Parker ME, Phillips BL, Huffman TN, Bay CP, Hudgens MG, Wiseman RW, Pollara JJ, Fouda GG, Ferrari G, Pickup DJ, Kozlowski PA, Van Rompay KKA, De Paris K, Permar SR. Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques. mSphere. 2018 Jan 10;3(1). eCollection 2018 Jan-Feb.

*Mohr EL, Block LN, Newman CM, Stewart LM, Koenig M, Semler M, Breitbach ME, Teixeira LBC, Zeng X, Weiler AM, Barry GL, Thoong TH, Wiepz GJ, Dudley DM, Simmons HA, Mejia A, Morgan TK, Salamat MS, Kohn S, Antony KM, Aliota MT, Mohns MS, Hayes JM, Schultz-Darken N, Schotzko ML, Peterson E, Capuano S 3rd, Osorio JE, O’Connor SL, Friedrich TC, O’Connor DH, Golos TG. Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. PLoS One. 2018 Jan 30;13(1). eCollection 2018.

*Acknowledges the WNPRC
** Affiliate or collaborative publication

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